DESeq2 with 3 treatment +3 genotype
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Entering edit mode
@hussienfotoh-18283
Last seen 7.0 years ago

Hello,

I am analyzing my experiment using DESeq2 I have 3 genotypes (1 Control + 2 mutants) and 3 treatments (1 Control + 2 treatments) and I have 4 technical replicates for each sample, I have done the count for the raw reads using HTSeq and I have the counts data, I need to get the differences between genotypes and treatments. which model should I use for my experiment?
Thank you

this is how the sample file look like:

sampleID    cultivar    treatment    

g1-1    g1    Control

g1-2    g1    Control    

g1-3    g1    Control        

g1-4    g1    Control

g1-1    g1    Treat1 

g1-2    g1    Treat1

g1-3    g1    Treat1

g1-4    g1    Treat1

g1-1    g1    Treat2

g1-2    g1    Treat2

g1-3    g1    Treat2

g1-4    g1    Treat2

g2-1    g2    Control

g2-2    g2    Control    

g2-3    g2    Control        

g2-4    g2    Control

g2-1    g2    Treat1 

g2-2    g2    Treat1

g2-3    g2    Treat1

g2-4    g2    Treat1

g2-1    g2    Treat2

g2-2    g2    Treat2

g2-3    g2    Treat2

g2-4    g2    Treat2

g3-1    g3    Control

g3-2    g3    Control    

g3-3    g3    Control        

g3-4    g3    Control

g3-1    g3    Treat1 

g3-2    g3    Treat1

g3-3    g3    Treat1

g3-4    g3    Treat1

g3-1    g3    Treat2

g3-2    g3    Treat2

g3-3    g3    Treat2

g3-4    g3    Treat2

 

 

 

deseq2 • 686 views
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Entering edit mode
@mikelove
Last seen 3 days ago
United States

Can you describe the nature of the replicates? Is it the same sample sequenced multiple times? If so you can follow code in the vignette to collapse these technical replicates.

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