Hi again, Since I had some troubles with memory and RMA I moved to the new version and here is what I got: > data<-ReadAffy() ... finally here, it went to the end of the process, but > data2<-rma(data) Note: http://www.bioconductor.org/data/cdfenvs/repos/ does not seem to have a valid repository, skipping Note: argument `lib' is missing: using C:/PROGRA~1/R/rw1062/library Error in update.packages2(pkgs, repEntry, lib, recurse, type, force = force, : Supplied repEntry argument does not point to a valid repository. There I am .. lost ! Philippe [[alternate HTML version deleted]]