What exactly do you mean by 'work with compressed files'? That could encompass many things - being specific in your questions is the only way you can expect to get useful answers.

This is probably related to your question https://www.biostars.org/p/415326 Please make sure to follow up there. In R you will have the same issue which users already pointed out at Biostars which is that a 32GB computer cannot load a 67GB file into memory.

I recommend you follow up on that Biostars post, explain what exactly you want to do and why the chunk-wise processing that users suggested is not sufficient.