when i bioconductor::install ("MetaDE"). IT'S GOING WRONG .

> BiocManager::install("MetaDE")
Bioconductor version 3.11 (BiocManager 1.30.10), R 4.0.0 (2020-04-24)
Installing package(s) 'MetaDE'
Installation path not writeable, unable to update packages: boot, class, foreign,
  KernSmooth, MASS, nnet, spatial
Old packages: 'ellipsis', 'glue'
Update all/some/none? [a/s/n]: 
a

  There are binary versions available but the source versions are later:
         binary source needs_compilation
ellipsis  0.3.0  0.3.1              TRUE
glue      1.4.0  1.4.1              TRUE

  Binaries will be installed
try to open URL’https://mirrors.tuna.tsinghua.edu.cn/CRAN/bin/windows/contrib/4.0/ellipsis_0.3.0.zip'
Content type 'application/zip' length 44558 bytes (43 KB)
downloaded 43 KB

try to open URL’https://mirrors.tuna.tsinghua.edu.cn/CRAN/bin/windows/contrib/4.0/glue_1.4.0.zip'
Content type 'application/zip' length 158875 bytes (155 KB)
downloaded 155 KB

package ‘ellipsis’ successfully unpacked and MD5 sums checked
Warning: cannot remove prior installation of package ‘ellipsis’
Warning: restored ‘ellipsis’
package ‘glue’ successfully unpacked and MD5 sums checked
Warning: cannot remove prior installation of package ‘glue’
Warning: restored ‘glue’

The downloaded binary packages are in
    C:\Users\lenovo\AppData\Local\Temp\RtmpOuJFAj\downloaded_packages
Warning messages:
1: package ‘MetaDE’ is not available (for R version 4.0.0) 
2: In file.copy(savedcopy, lib, recursive = TRUE) :
 Copy C:\Users\lenovo\Documents\R\win-library\4.0\00LOCK\ellipsis\libs\x64\ellipsis.dll to C:\Users\lenovo\Documents\ libs\x64\ellipsis.dll with Permission denied
3: In file.copy(savedcopy, lib, recursive = TRUE) : 
Copy C:\Users\ Documents\R\win-library\4.0\00LOCK\glue\libs\x64\ glgles.dll to C:\Users\ Documents\ libs\x64\ glgles.dll: Permission denied

 >

Hey,

MetaDE is not a Bioconductor package and, in fact, it is not even anymore in the CRAN repository - it was removed from CRAN in January, 2018: https://cran.r-project.org/web/packages/MetaDE/index.html

It seems that some now recommend metap (CRAN). My own personal recommendations are:

• GenRank (Bioconductor)
• RankProd (Bioconductor)

If you must use MetaDE, then you could try to install the last known version by downloading from here, and then using, for example:

install.packages('MetaDE_1.0.5.tar.gz', repos = NULL, type = 'source')

The Github repo for the package can also still be installed:

devtools::install_github('metaOmics/MetaDE')

--------------------

Kevin