Hello!
I have a really basic question!
In the DiffBind
vignette, I have a question regarding the following texts:
If bFullLibrarySize is set to TRUE (default), then sizeFactors is called with the number of reads in the BAM/BED files for each ChIP sample, divided by the minimum of these; otherwise, estimateSizeFactors is invoked.
How does DiffBind
internally calculates the number of reads of a BAM file to make those sizeFactors? In particular, which R package?
Thank you very much in advance!