A user who I am helping to learn R and BioC has the following problem. He is trying to use justRMA to normalize a set of affy CEL files. He is on MacOS and is running R-2.2.1 (I know, upgrade, but....). Here is what he describes: > sessionInfo() R version 2.2.1, 2005-12-20, powerpc-apple-darwin7.9.0 attached base packages: [1] "tools" "methods" "stats" "graphics" "grDevices" "utils" "datasets" "base" other attached packages: affy Biobase "1.8.1" "1.8.0" > library(affy) Loading required package: Biobase Loading required package: tools Welcome to Bioconductor Vignettes contain introductory material. To view, simply type 'openVignette()' or start with 'help(Biobase)'. For details on reading vignettes, see the openVignette help page. > est <- justRMA() trying URL 'http://bioconductor.org/packages/data/annotation/1.7/bin/macosx/power pc/con trib/2.2/hgu133plus2cdf_1.10.0.tgz' Content type 'application/x-gzip' length 4391892 bytes opened URL ================================================== downloaded 4288Kb Error in sprintf(gettext(fmt, domain = domain), ...) : argument is missing, with no default tar: ~/Library/R/library/file56e509fe: Cannot chdir: No such file or directory tar: Error is not recoverable: exiting now > Any hints? Thanks, Sean