Limited spaces remain for the Boston course. data analysis for high-throughput biology open source approaches with Bioconductor three day short course, Longwood Medical Area July 13-15 2006 registration materials at http://www.biostat.harvard.edu/~carey/bos06formal.html This course has a new structure/content. Modules (to be covered at a rate of approximately 3/day): *Taster: Gene expression in airways hyperresponsiveness; annotation, gene set enrichment; transcript profiling in the yeast cell cycle; genetical genomics of human chromosome 20 *Interacting with R and Bioconductor: websites, packages, documentation, community *Bioconductor: data structures and workflow components *Microarray workflow: focus on affy$^{tm}$ expression arrays: CEL files + phenoData = AffyBatch; basic QC; spikein data and comparison of preprocessing methods; affyPLM; affylmGUI; other technologies *Gene filtering: mechanics: closure of exprSet class under subsetting; subject-matter: ontology; pathways *Exploratory data analysis (unsupervised learning):} general resources in R; visualization; distances, clustering, heatmaps; PCA, biplots *Differential expression analysis (transcript profiling) *Annotation resources: chip-specific mapping environments; probe sequence access; organismic metadata: YEAST; genomic sequences; systems biology resources: GO, KEGG, cMAP; specific web services: biomaRt, RSNPper, RMAPPER *Methodology for functional gene set analysis *Classification; supervised learning: distances; generalization error and discriminatory capacity; nearest neighbor methods; recursive partitioning and derivatives (random forests); boosting; svm *Project: linking airways hyperresponsiveness arrays to genetical genomics resources http://www.bioconductor.org --- Vince Carey, PhD Assoc. Prof Med (Biostatistics) Harvard Medical School Channing Laboratory - ph 6175252265 fa 6177311541 181 Longwood Ave Boston MA 02115 USA stvjc at channing.harvard.edu