Hi Bioc I am using cph in the library Design so that I can compare the log likehood ratio test for different nested cox models. I am testing about 50 genes. Whilst I can use p.adjust to correct for multiple testing, I get a few gene with low expression levels, which may have low variance by chance. Is there an ebayes (limma) like correction I can apply? Or can I modify this for cph? Thanks Aedin -- Aed?n Culhane Harvard School of Public Health, Dana-Farber Cancer Institute