Dear all, We have a number of research and programming positions available in Computational biology and Bioinformatics: The Paterson Institute for Cancer Research in Manchester is a leading cancer centre of excellence core-funded by Cancer Research UK, the largest independent cancer research organisation in the world. The Institute supports numerous basic and translational cancer research programmes and has a wide range of state-of-the-art research services. It is located adjacent to the Christie Hospital, a specialist cancer hospital, thereby ensuring ample opportunities for interaction across the basic to clinical research spectrum. The Institute is also at the heart of the newly formed Manchester Cancer Research Centre (MCRC). A number of positions are available within the Applied Computational Biology Group for scientists interested in joining a multidisciplinary team and using the latest in high throughput technology to further our understanding of cancer. Post 1: Postdoctoral Researcher Recent work has shown that a significant proportion of the human genome is transcribed, and that a substantial fraction of this non-coding RNA plays a functional role within cells. We are seeking a postdoctoral research scientist with a PhD in computational biology (or a related discipline), to investigate the behaviour of these genomic regions in cancer. The successful applicant will work in collaboration with both clinical- and basic-scientists on research involving new technologies including next generation sequencing and high density tiling microarrays. The project will involve analysing genome wide data generated from a mixture of clinical and cell-line samples, with a focus on non-coding RNA and its interactions with other molecules. The goal is to indentify new players in the regulation and control of cancer. Post 2: Postdoctoral Researcher We are seeking a postdoctoral scientist to analyse high throughput clinical microarray datasets. The post will involve working as part of a multidisciplinary international collaboration investigating patient outcome, and will involve dealing with large quantities of Affymetrix Exon microarray data. The successful applicant will have a PhD in computational biology (or a related discipline), be statistically adept, and have significant experience interpreting gene expression data. Strong communication skills are essential, as is a desire to generate software tools and approaches with direct practical applications. The goals are (i) to indentify novel sets of genes that can be used to help support patient diagnoses and (ii) to develop and validate real time PCR based approaches with which to apply these gene sets in the clinic. Post 3: Computer programmer We are looking for a computer programmer with a strong background in Java and/or C who is inspired by science and technology and enjoys exploring new programming languages and techniques. The successful applicant will be interested in learning about the human genome and the role it plays in cancer. The post will involve developing new software tools for the analysis of genome-scale data generated using a variety of technologies, including high throughput sequencing, mass spectrometry and high density tiling microarrays. For this position, detailed biological knowledge is less critical than excellent programming skills, creative problem solving, and the ability to communicate well with scientists and researchers from different disciplines. You will be qualified to degree level in computer science or a related discipline. For posts 1 and 2, the deadline for receipt of applications is the 4th December, for post 3, the 26th November. For more details, see our website at www.paterson.man.ac.uk. Best wishes, Crispin -------------------------------------------------------- This email is confidential and intended solely for the u...{{dropped:15}}