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On Mon, Nov 24, 2008 at 10:43 PM, Amin Momin <gtg269c@mail.gatech.edu>wrote: > HI, > I am interested in knowing if it is advisible to combine microarray data > from the dame platform for different cell lines for normalization and > analysis. Recently I noticed that this was done at the Genomic foundation of > novartis web portal for the NCI60 cell lines. They have merged NCI60 cell > data with another 40 cancer cell lines. I was wondeing if some some has > experience with this and under what condition will this be a valid protocol. > Hi, Amin. This is generally not advisable as lab-to-lab and other technical variation is typically a significant factor. Sean [[alternative HTML version deleted]]