Hello, I was just trying to update Bioconductor (I'm running R1.8.0) under w2k via the reposTools. However, I did not succeed. Here's the messages: > install.packages2(method="wget") Note: argument `lib' is missing: using C:/PROGRA~1/R/rw1080/library Note: http://www.bioconductor.org/CRANrepository does not seem to have a valid repository, skipping Note: http://www.bioconductor.org/repository/release1.2/package does not seem to have a valid repository, skipping Note: http://www.bioconductor.org/repository/devel/package does not seem to have a valid repository, skipping Note: http://www.bioconductor.org/data/dataRepos does not seem to have a valid repository, skipping Note: http://www.bioconductor.org/repository/Courses does not seem to have a valid repository, skipping Error in update.packages2(method = "wget") : No repositories to search I'm behind a firewall (proxy + user authentification), but update.packages("scatterplot3d") works: > install.packages("scatterplot3d", method="wget") package scatterplot3d successfully unpacked and MD5 sums checked Delete downloaded files (y/N)? The packages are in C:\DOCUME~1\S8310956\LOCALS~1\Temp\Rtmp31446\Rinstdir16535 updating HTML package descriptions > Stangely - the installation of the reposTools itself via getBioC(method="wget") works. Maybe there's something wrong with the BioC site? Please let me know if you've any suggestions, thanks for your help, Arne