You can install a source package on any platform; for windows it just happens to take a bit of work, although these days it is only a trivial amount of work. See here http://cran.r-project.org/bin/windows/base/rw-FAQ.html#Can-I-install- packages-into-libraries-in-this-version_003f Best, Jim James W. MacDonald, M.S. Biostatistician Douglas Lab 5912 Buhl 1241 E. Catherine St. Ann Arbor MI 48109-5618 734-615-7826 >>> Jordi Altirriba 11/25/10 4:18 AM >>> Dear Bioconductor users, I am trying to work with CORNA.1.2. package to observe how miRNA regulates mRNA expression levels, as described in Wu X, Watson M, CORNA: testing gene lists for regulation by microRNAs, Bioinformatics. 2009 Mar 15;25(6):832-3. I have downloaded this package from the authors? webpage: http://corna.sourceforge.net/ Nevertheless, this package was compiled with a version previous than R.2.10.0, so I am not able to run it in R.2.12.0 version (current version). I have downloaded R.2.9.0 version and I am able to load CORNA package but biomaRt is not running (BioMart web service failed) [sessionInfo below]. It?s not a problem of BioMart web service, as in R.2.12.0 BioMart is running correctly. My questions: 1.- Is there any way to run BioMart in previous versions of R? (R.2.9.0 or previous) 2.- If it?s not possible, could I recompile CORNA package to run in R.2.12.0? How? 3.- Is there any other package to associate miRNA expression levels from microarrays with mRNA expression levels from other microarrays? (I am working with rats and mice and MMIA is not working with these species) Many thanks for your time and suggestions. Yours faithfully, Jordi Altirriba Laboratoire du M?tabolisme Centre M?dical Universitaire Geneve > sessionInfo() R version 2.9.0 (2009-04-17) i386-pc-mingw32 locale: LC_COLLATE=French_Switzerland.1252;LC_CTYPE=French_Switzerland.1252;LC _MONETARY=French_Switzerland.1252;LC_NUMERIC=C;LC_TIME=French_Switzerl and.1252 attached base packages: [1] tools stats graphics grDevices utils datasets methods base other attached packages: [1] CORNA_1.2 XML_2.5-1 GEOquery_2.8.0 RCurl_0.98-1 bitops_1.0-4.1 biomaRt_2.0.0 Biobase_2.4.1 _______________________________________________ Bioconductor mailing list Bioconductor at stat.math.ethz.ch https://stat.ethz.ch/mailman/listinfo/bioconductor Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor ********************************************************** Electronic Mail is not secure, may not be read every day, and should not be used for urgent or sensitive issues