Hi, Is there any known bug in the function maNorm2D() ? I am trying to use it with the swirl data set, but after calling it as: swirl.C<-maNormMain(swirl, f.loc = list(maNorm2D())) the result seems to be a downward shift of all M values with about 10 decades on the log2 scale which is a nonsense. Thanks -------------------------------------------- Laurentiu Adi Tarca Post Doc. en Bioinformatique Centre de Recherche en Biologie Foresti?re Pavillon Marchand, 3113 Universit? Laval Qu?bec, Qu?bec G1K 7P4 Tel: 656-2131 ext. 4509 e-mail: ltarca@rsvs.ulaval.ca