Dear all, Unfortunately, it seems that the KEGG FTP will be a paid service in the near future. I imagine this will have a strong impact on many of the current tools and resources used by the scientific community in general and by the bioconductor community in particular. See the link: http://www.kegg.jp/kegg/docs/plea.html -- Diego Diez, PhD Bioinformatics center, Institute for Chemical Research, Kyoto University. Gokasho, Uji, Kyoto 611-0011 JAPAN diez at kuicr.kyoto-u.ac.jp