Hi, I'd like to use GOSemSim to calculate the functional similarity between yeast and human proteins. It looks like it can compare human with human and yeast with yeast, but not proteins between species. Having looked at the documentation I assume the important change is to create a new information contents file that combines the yeast and human ones. However, I can't work out how to do this. Is this the correct approach to take, and does anyone have any advice on how to do so? Thanks and best wishes, Katharine Coyte 1st Year DPhil Candidate Systems Biology DTC University of Oxford [[alternative HTML version deleted]]

CC'ing the maintainer of GOSemSim. Dan On Tue, Jun 5, 2012 at 3:02 AM, Katharine Coyte <katharine.coyte at="" jesus.ox.ac.uk=""> wrote: > Hi, > > I'd like to use GOSemSim to calculate the functional similarity between yeast and human proteins. It looks like it can compare human with human and yeast with yeast, but not proteins between species. > > Having looked at the documentation I assume the important change is to create a new information contents file that combines the yeast and human ones. However, I can't work out how to do this. Is this the correct approach to take, and does anyone have any advice on how to do so? > > Thanks and best wishes, > > Katharine Coyte > > 1st Year DPhil Candidate > Systems Biology DTC > University of Oxford > > ? ? ? ?[[alternative HTML version deleted]] > > _______________________________________________ > Bioconductor mailing list > Bioconductor at r-project.org > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor