Question: DESeq2 : when the variable of interest is not a factor

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Marie Sémon •

**50**wrote:Dear all,
I wish to find genes whose expression profile correlates with a
variable
of interest, which is quantitative (say, the weight of the
individuals).
Is it possible/a good practice to use DESeq2 for this?
One one hand the vignette clearly describes factors (qualitative)
variables, but, on the other hand there is this sentence, p8:
"If the variable of interest is not a factor, the log2 fold change can
be interpreted as the amount of doubling observed on average for every
unit of change."
Many thanks for you help
With kind regards,
Marie

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modified 5.6 years ago
by
Jose M Garcia Manteiga •

**310**• written 5.6 years ago by Marie Sémon •**50**