Dear all, Recently I'm reading the paper "Moderated statistical tests for assessing differences in tag abundance"(http://bioinformatics.oxfordjo urnals.org/content/23/21/2881.full.pdf+html) In part 3.2 where the estimation algorithm was stated, I have trouble understanding ALGORITHM STEP (3). My question was, How does the equation in STEP (3) relate to that in equation (4), the one right above this paragraph? I'm confused especially by the denominator( I_g(1+I_g\tau_0^2) )in the bracket. Is there any reference about on this particular point? Thanks, Bin Zhuo -- output of sessionInfo(): None -- Sent via the guest posting facility at bioconductor.org.

Dear Bin Zhuo, I answered this question when you mailed it to me individually. There is no need to send duplicate emails. Thanks Gordon --------------------------------------------- Professor Gordon K Smyth, Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Vic 3052, Australia. http://www.statsci.org/smyth > Date: Thu, 7 Nov 2013 12:32:45 -0800 (PST) > From: "Bin Zhuo [guest]" <guest at="" bioconductor.org=""> > To: bioconductor at r-project.org, zhuob at stat.oregonstate.edu > Subject: [BioC] On empirical Bayes of edgeR > > > Dear all, > > Recently I'm reading the paper "Moderated statistical tests for > assessing differences in tag > abundance"(http://bioinformatics.oxfordjournals.org/content/23/21/28 81.full.pdf+html). > > In part 3.2 where the estimation algorithm was stated, I have trouble > understanding ALGORITHM STEP (3). My question was, How does the equation > in STEP (3) relate to that in equation (4), the one right above this > paragraph? I'm confused especially by the denominator( > I_g(1+I_g\tau_0^2) )in the bracket. Is there any reference about on > this particular point? > > Thanks, > Bin Zhuo > > -- output of sessionInfo(): > > None > > -- > Sent via the guest posting facility at bioconductor.org. ______________________________________________________________________ The information in this email is confidential and intend...{{dropped:4}}