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Question: DEXSeq dispersion trend estimation?
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gravatar for Ryan C. Thompson
4.2 years ago by
The Scripps Research Institute, La Jolla, CA
Ryan C. Thompson6.8k wrote:
Hello, I am trying to understand the methods used in DEXSeq, and I was hoping you could clear up some of the details of the dispersion trend squeezing strategy. In particular, when fitting the dispersion-mean trend, what is used as the mean for a given exon? Is this computed only based on the exon's own counts, or is it the mean of all the counts for that exon, including the sum of counts in other exons? If it is the latter, wouldn't the mean be identical for every exon in the same gene, since the total counts for that gene are constant, and if so, is this the intended effect? Thanks, -Ryan Thompson
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