readVcf error resulting from star * in alt allele field
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@christian-ruckert-3294
Last seen 5.4 years ago
Germany
I get the following error when trying to read in a VCF file:

Error in .Call2("new_XStringSet_from_CHARACTER", ans_class, ans_elementType,  : 
  key 42 (char '*') not in lookup table

 

The problematic entry is:

3    37067095    .    ATATATTTTTT    *    11571.2    PASS    AC=1;AC_Orig=7;AF=0.5;AF_Orig=0.438;AN=2;AN_Orig=16;BaseQRankSum=-1.019;DP=2420;ExcessHet=3.01;FS=7.334;MQ=60;MQRankSum=0.356;QD=8.69;ReadPosRankSum=2.07;SOR=1.365    GT:AD:GQ:PL:SAC    0/1:121,56:99:1570,0,4899:86,35,0,0,47,9

 

The * character was introduced in VCF 4.2 to indicate that the allele is missing due to an upstream deletion.

Regards,

Christian

variantannotation • 1.7k views
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@valerie-obenchain-4275
Last seen 2.9 years ago
United States

Hi,

Support for '*' was added in VariantAnnotation 1.15.31 in devel. The Bioconductor 3.2 release is next week (Oct 14) at which time devel becomes release so the fix will be in both branches. If you can use devel, this is available right away with biocLite().

Valerie

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Hi,

I am using VariantAnnotation 1.16.1, but I get the same error:
Error in .Call2("new_XStringSet_from_CHARACTER", ans_class, ans_elementType,  :
  key 42 (char '*') not in lookup table

Do you have an idea about why it is not working, when I am using this version?

Josephine

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Support for '*" is available in >= 1.16.0 so I'm not sure why this isn't working for you. Please show the output of sessionInfo() in the R session where you get the error.

If you can send me the file (valerie.obenchain@roswellpark.org) I can take a look.

Valerie

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Thanks for sending the file. This was a bug and is now fixed in devel (1.17.6) and release ( 1.16.3). Both should be available via biocLite() tomorrow by noon PST or svn immediately. 

Valerie

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