Question: multtest bug fixed
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gravatar for kpollard
14.5 years ago by
kpollard110
United States
kpollard110 wrote:
Hello All, I've just found and fixed a bug in the boot.resample function of the multtest package. This function is called by the function MTP. So, if you have been using the MTP function with multtest version 1.5.x, you may have incorrect p-values (rawp and adjp). Other functions, such as mt.minP, mt.maxT and mt.rawp2adjp do not use this function and are OK. The problem was that when standardizing the test statistics null distribution, we used min where we needed pmin. The consequence was that each marginal null distribution was standardized by 1/variance of the gene with the largest variance (not its own variance). Hence, the marginal test statistics null distributions were too narrow and more rejections were made than should have been (ie: pvalues were smaller than they should have been). I have checked this correction into the cvs archive today and the fixed package should be available under developmental packages soon. Version 1.6 (for the upcoming BioC release) will be corrected also. Apologies for any inconvenience. Best, Katie
multtest • 396 views
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