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Question: seeking a paper or journal review about repeated multiple testing for Biological ChIP-seq replicates?
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gravatar for Jurat Shahidin
14 months ago by
Italy
Jurat Shahidin60 wrote:

Dear all:

I need to understand multiple repeated testing for biological ChIP-seq replicates, to observe test variation in repeated multiple test. Can anyone tell me any related papers, journal review to explain the topic that I raised? I also prefer to look at any existing Bioconductor packages that implement multiple repeated testing for ChIP-seq replicates. Thanks a lot.

Best regards:

Jurat

ADD COMMENTlink modified 14 months ago by Gordon Smyth31k • written 14 months ago by Jurat Shahidin60
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gravatar for Gordon Smyth
14 months ago by
Gordon Smyth31k
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Gordon Smyth31k wrote:

As far as I know, there is no statistical method called "repeated multiple testing" or "multiple repeated testing".

If you simply mean "multiple testing", then you might look at the csaw package:

The csaw package is able to handle biological replicates and multiple experimental factors.

ADD COMMENTlink modified 14 months ago • written 14 months ago by Gordon Smyth31k

Dear Gordon Smyth:

Thanks a lot for your quick respond here. I definitely look at that packages.

I aware that there is a case that repeating ChIP-seq replicates in several times, where each test would yield corresponding different experiment results, so I want to understand behind ideas of repeating test, and try to figure out test variation of one to another.Thank you

Best regards:

JuratĀ 

ADD REPLYlink modified 14 months ago • written 14 months ago by Jurat Shahidin60
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