seeking a paper or journal review about repeated multiple testing for Biological ChIP-seq replicates?
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@jurat-shahidin-9488
Last seen 4.0 years ago
Chicago, IL, USA

Dear all:

I need to understand multiple repeated testing for biological ChIP-seq replicates, to observe test variation in repeated multiple test. Can anyone tell me any related papers, journal review to explain the topic that I raised? I also prefer to look at any existing Bioconductor packages that implement multiple repeated testing for ChIP-seq replicates. Thanks a lot.

Best regards:

Jurat

bioinformatics paper multiple treatments biologicalreplicates • 1.2k views
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@gordon-smyth
Last seen 50 minutes ago
WEHI, Melbourne, Australia

As far as I know, there is no statistical method called "repeated multiple testing" or "multiple repeated testing".

If you simply mean "multiple testing", then you might look at the csaw package:

The csaw package is able to handle biological replicates and multiple experimental factors.

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Dear Gordon Smyth:

Thanks a lot for your quick respond here. I definitely look at that packages.

I aware that there is a case that repeating ChIP-seq replicates in several times, where each test would yield corresponding different experiment results, so I want to understand behind ideas of repeating test, and try to figure out test variation of one to another.Thank you

Best regards:

JuratĀ 

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