I'm a budding researcher learning edgeR primarily by reading through the official User's Guide. I'm analyzing an RNA-seq dataset with six samples, three in each of two groups. I found the User's Guide a bit cryptic as to whether I should use the classic edgeR approach (exactTest) or the GLM functionality (glmQLFTest). I understand the classic approach is useful for experiments with only a single factor, like mine, but the authors of the User's Guide often used the glm approach in examples even with a single factor. Any tips?