Hi there, I'm new to methylation data analysis. Now I have extracted a ratio set and coverted it to a genomic ratio set by mapToGenome() in minfi. I wish to do a DMR analysis using bumphunter(). However, it seems like that bumphunter() only accepts a matrix-backed minfi object? What should I do.

dmrs=bumphunter(GRset, design = designMatrix, cutoff = 0.2, B=1000, type="Beta")

Error: 'bumphunter()' only supports matrix-backed minfi objects.

Thanks for any help!!