Where do the filename come from in the LOLA datasets?
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@lluis-revilla-sancho
Last seen 11 days ago
European Union

I am using the dataset provided for LOLA to analyze my data (hg38). In the files generated when saving the results with writeCombinedEnrichment I see new columns:

dataSource              filename
ENCODE segmentation Helas3_T.bed

What are these .bed files and where to find them?

In the website there is a link to https://hgdownload.cse.ucsc.edu/goldenPath/hg19/encodeDCC/wgEncodeAwgTfbsUniform/ but that file or similar files are not present there. Even after accounting that narrowPeak is a .bed format, there are just three files about Helas3 wit no mention of T: wgEncodeAwgTfbsBroadHelas3CtcfUniPk.narrowPeak.gz, wgEncodeAwgTfbsBroadHelas3Ezh239875UniPk.narrowPeak.gz wgEncodeAwgTfbsBroadHelas3Pol2bUniPk.narrowPeak.gz

LOLA • 710 views
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@nathan-sheffield-7613
Last seen 14 months ago
University of Virginia

The default LOLA database has files from multiple sources. The ones you're referring to are from segmentations, It was many years ago that I assembled that database, but I believe those ones came from the Segmentation tracks from UCSC -- I think this was probably the ChromhmmHelas3, or maybe the CombinedHelas3 segmentation, and T would have been the state called for those regions by that segmentation.

You can find the original files here: https://genome.ucsc.edu/cgi-bin/hgFileUi?db=hg19&g=wgEncodeAwgSegmentation

Let me know if this doesn't answer your question, and I can dig a bit deeper.

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