I have to analyze following experimental design 

I basically have various type of tissues from wildtype mouse ( 8 tissues numbered 1-8) I would like to check for gene expression and junction usage differences between the tissues using deseq2 and dexseq respectively, what should be the right approach for design model and what kind of functions should i be using to achieve this? (apologies for such an open ended question) historically have always performed wt vs mt , any help appreciated.