THE CANCER RESEARCH UK MANCHESTER INSTITUTE

Postdoctoral Scientist - Systems Oncology Group

•Job Ref: MI/17/25

•Salary starting: £30,000 - £39,800 (depending on qualifications and experience)

•Duration: 3 years

Dr Claus Jorgensen, Group Leader of the Systems Oncology Group, is looking for a Postdoctoral scientist to join his group. This is a great opportunity for a self-motivated, innovative and organised candidate with excellent communication skills to work in a dynamic laboratory undertaking cutting edge research.

The goal of the Systems Oncology Group is to understand how aberrations in cellular signalling affect tumour progression and response to therapy. In particular, we are interested in understanding how signalling between cancer cells and cells in the tumour microenvironment promote tumour progression and drug resistance. Using global approaches such as proteomics, RNA interference screening and RNA sequencing we aim to identify and understand the mechanisms of cell-cell communication (Tape et al Cell 2016, Jorgensen et al Science 2009, Tape et al Mol Cell Proteomics 2014, Tape et al Anal Chem 2014, Worboys et al Nature Methods 2014). The successful candidate will join a multidisciplinary team to study these problems.

The successful candidate will develop an independent research project to address how cells in the tumour stroma influence tumour cell therapeutic response. Key to the success of the project will be integration of quantitative signalling data (proteomics data and single cell CyTOF data) with phenotypic data (e.g. apoptosis, proliferation etc). The successful applicant is expected to be competent in data analysis of cellular signalling using computational tools (for example SVM, Bayesian, ODE, PLSR etc). Specifically the candidate should be experienced in computational analysis of high dimensional data either from FACS, CyTOF, imaging or proteomics and have demonstrated ability to develop data-driven models. While wet-lab experience is not a requirement, it is an advantage. In particular, experience in FACS, CyTOF, high-content imaging or other types of single cell data is also advantageous. Finally, the post holder will be expected to interact with members in the laboratory and contribute to the design and development of on-going proteomics research projects in support of the Systems Oncology group.

The successful applicant should have a PhD in computational biology, systems biology, cell biology, biochemistry or a relevant field. Experience in computational data analysis of cellular signalling (information processing) is essential.

Informal enquiries can be directed to Dr Claus Jorgensen via email: claus.jorgensen@cruk.manchester.ac.uk

The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk) is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org) the largest independent cancer research organisation in the world. We are adjacent to The Christie NHS Foundation Trust (www.christie.nhs.uk) one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients.

To apply for this position please visit our website: www.cruk.manchester.ac.uk/jobs

Closing date: 13 July 2017.