I am doing a differential abundance analysis in R using metagenomeSeq. I'm trying to see if there are any differences in ASV's and phlya between those with and without cognitive impairment. My understanding is that metagenomeseq will run a model where the independent variable is Cognitive Impairment (Yes or No) and the dependent variable is the counts for the ASV/phyla. Is this correct? Or is it the other way around - the dependent variable is Cognitive Impairment (Yes or No) and the independent variable is ASV/phyla count? Thank you!