Question: GO analysis under-represented genes and over-represented (enrichment) down-regulated genes
gravatar for Jack
11 months ago by
Jack0 wrote:

I did GO enrichment analysis on all of the DE genes, up-regulated genes and down-regulated genes separately.

Since over-represented (enrichment) are easy to understand, I want to know what is the biological significance of under-represented genes?

Can I say under-represented genes have similar biological significance with over-represented (enrichment) down-regulated genes ?

ADD COMMENTlink modified 11 months ago • written 11 months ago by Jack0

there is no  under-representation test implemented in clusterProfiler.

ADD REPLYlink written 11 months ago by Guangchuang Yu1.0k

Yes, I know that. I want to know if it is necessary to do under-represented genes analysis...

ADD REPLYlink written 11 months ago by Jack0
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