GO analysis under-represented genes and over-represented (enrichment) down-regulated genes
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Jack ▴ 20
@jack-14069
Last seen 5.1 years ago

I did GO enrichment analysis on all of the DE genes, up-regulated genes and down-regulated genes separately.

Since over-represented (enrichment) are easy to understand, I want to know what is the biological significance of under-represented genes?

Can I say under-represented genes have similar biological significance with over-represented (enrichment) down-regulated genes ?
go rnaseq clusterprofiler topgo • 1.7k views
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there is no  under-representation test implemented in clusterProfiler.

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Yes, I know that. I want to know if it is necessary to do under-represented genes analysis...

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