Question: How to select mergeCutHeight in WGCNA?
0
gravatar for harelarik
23 months ago by
harelarik10
harelarik10 wrote:

Hi,

 

What is would be a good way to select mergeCutHeight for modules generation with  blockwiseModules?

 

 

 

Thank you,

 

Arik

 

wgcna mergecutheight • 1.1k views
ADD COMMENTlink modified 23 months ago by Peter Langfelder2.3k • written 23 months ago by harelarik10
Answer: How to select mergeCutHeight in WGCNA?
2
gravatar for Peter Langfelder
23 months ago by
United States
Peter Langfelder2.3k wrote:

I am not aware of a principle from which one could derive an "appropriate" value, but in practice, on data sets with 50-100 samples, using 0.15 to 0.2 has worked fairly well. For fewer samples a larger valuse (0.25 to 0.3) may be warranted. If you want larger modules, increase the value; if you want smaller modules at the risk of having redundant modules (modules with very similar functional annotation and very similar fuzzy module membership), you can decrease the value to say 0.10, maybe even lower if you have lots of samples (hundreds or more).

HTH

Peter

ADD COMMENTlink written 23 months ago by Peter Langfelder2.3k

Thank you!

ADD REPLYlink written 23 months ago by harelarik10
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