Postdoctoral Position: Posttranscriptional gene regulation in T cells

The Molecular Immune Regulation group at the Department of Biomedicine of the University of Basel and Basel University Hospital in Switzerland is seeking a highly motivated postdoc to work at the intersection of immunology, computational biology and molecular biology. We have recently developed a CRISPR/Cas9-based approach for T cell genome engineering (Kornete et al., The Journal of Immunology, 2018). The current project applies this and refined methods to dissect miRNA/gene networks in T cells.

Your position

• You combine analysis of RNA-Seq, CLIP and metabolomics data with wet lab work to perturb genetic networks in T cells
• You employ a variety of genome engineering approaches in T cells (CRISPR/Cas9, Cpf-1, HDR, base editors) to experimentally validate your in silico analysis
• You actively contribute to interdisciplinary collaborations
• You contribute to validating results in mouse models

Your profile
The successful candidate is expected to have:

• PhD, MD or MD PhD degree in immunology, cell/molecular biology or computational biology
• The ideal candidate has a strong background in immunology (including hands-on work) combined with practical experience analyzing "omics" data (e.g. RNA-Seq, metabolomics)
• You enjoy combining computational analysis with bench work
• Solid theoretical and practical background in molecular biology. No prior genome engineering experience required.
• You have good communication skills and enjoy interdisciplinary work
• Experience working with mice is a plus

We offer you

• Well-funded research group focused on improving the molecular understanding of immune regulation and the development of next generation therapeutic concepts.
• Cutting-edge, challenging science in a stimulating environment with state-of-the art equipment, flexible working hours
• Integration to a lively immunology community. Collaboration with in-house bioinformatics core facility and Prof. M. Zavolan's group.
• Competitive salary according to guidelines of the University of Basel/Swiss National Science Foundation. Location in the heart of Europe

Application / Contact
Please send a motivation letter, CV and contact information including e-mail address of three references to: Regan Geissmann r.geissmann@unibas.ch, assistant to Prof. Lukas Jeker, Experimental Transplantation Immunology & Nephrology. Please include "Gene Regulation Postdoc" in the subject line.

http://direktlink.prospective.ch/?view=d25efd3b-3605-4cad-a064-28c0fb832c45