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Homer
•
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@homer-18328
Last seen 4.8 years ago
I don't understand how DESeq2 calculates the p-values given by DESeq2::results()
. I thought it was
2 * pnorm(abs(log2FoldChange / lfcSE), lower.tail = FALSE)
with log2FoldChange
and lfcSE
taken from the corresponding columns of the output table given by DESeq2::results()
. However, when calculating the p-values this way, I get non-negligible differences (i.e. not only numerical inaccuracies) to the p-values given by DESeq2.