I guess this is not only specific to DESeq2 but also to other methods like edgeR, etc.
I do not have any data for this or any code. It is more of a general question.
Assume you have the following setup: - 5 Control samples - 5 Treated samples
Now, also assume that we have a rather "low effect" from the treatment on the expression of genes. Would you be surprised if you find more sign. DE expressed genes if you take only 4 treatment samples compared taking all of them (5 treatment samples). Or different: Is it a common effect to get less sign. DE genes if you have a higher sample size? Again, especially if you do not have strong effects from the treatment.