I'm following a tutorial for using MethylMix package for analyzing DNA methylation data, the problem is that the processing of the methylation data is soooo slow for being runned in my PC, so I need to run this script in a HPC cluster using the Slurm Workload Manager (this HPC uses MPI), but I had no idea about how to do it. Any suggestion?

library(MethylMix)
library(doParallel)

cancerSite <- "OV"
targetDirectory <- paste0(getwd(), "/")

cl <- makeCluster(4)
registerDoParallel(cl)

# Downloading methylation data
METdirectories <- Download_DNAmethylation(cancerSite, targetDirectory)
# Processing methylation data
METProcessedData <- Preprocess_DNAmethylation(cancerSite, METdirectories)
# Saving methylation processed data
# saveRDS(METProcessedData, file = paste0(targetDirectory, "MET_", cancerSite, "_Processed.rds"))

# Downloading gene expression data
GEdirectories <- Download_GeneExpression(cancerSite, targetDirectory)
# Processing gene expression data
GEProcessedData <- Preprocess_GeneExpression(cancerSite, GEdirectories)
# Saving gene expression processed data
saveRDS(GEProcessedData, file = paste0(targetDirectory, "GE_", cancerSite, "_Processed.rds"))

# Clustering probes to genes methylation data
METProcessedData <- readRDS(paste0(targetDirectory, "MET_", cancerSite, "_Processed.rds"))
res <- ClusterProbes(METProcessedData[[1]], METProcessedData[[2]])

# Putting everything together in one file
toSave <- list(METcancer = res[[1]], METnormal = res[[2]], GEcancer = GEProcessedData[[1]], 
               GEnormal = GEProcessedData[[2]], ProbeMapping = res$ProbeMapping)
saveRDS(toSave, file = paste0(targetDirectory, "data_", cancerSite, ".rds"))

stopCluster(cl)

Exact information for setting up MethylMix for parallel processing can be found here: https://www.bioconductor.org/packages/release/bioc/vignettes/MethylMix/inst/doc/vignettes.html

If you actually want help writing the submission script for your HPC, then please contact your System Administrator or Service Desk for that. There are different configurations and we are not to immediately know which is required in your case.

Kevin