Hi, I have a large number of CEL files (~4000) that I would like to rma normalise. Just reading in the files and rma normalising them is not possible as there are too many (allocMatrix: too many elements specified). justRMA also gives the same error. A possible solution seems to be using BufferedMatrix.justRMA. I have been trying this on a test set and for justRMA the following command works: > normalised_data<-justRMA(celfile.path="/data/cancther/emma/CEL_Files _Neoplasm/Test_CEL") Whereas for BufferedMatrix, with the appropriate packages loaded, I get the following error message: > normalised_data<-BufferedMatrix.justRMA(celfile.path="/data/cancther /emma/CEL_Files_Neoplasm/Test_CEL") Error in BufferedMatrix.justRMA(celfile.path = "/data/cancther/emma/CEL_Files_Neoplasm/Test_CEL") :   could not find function "read.celfile.header" Could someone please help me get around this? Thanks, Emma [[alternative HTML version deleted]]