I have two questions:
QUESTION 1. In metagenomeSeq:
# Calculate proper percentile to normalize data
percentile = cumNormStatFast(genusObj, pFlag = FALSE, rel = 0.1)
genusObj = cumNorm(genusObj, p = percentile)
If I substitute p = percentile by p = 1 , will metagenomeSeq perform total sum normalization?
Is it possible to conduct DESeq and TMM normalization using metagenomeSeq?
Many thanks in advance!