ratioConvert is not the right function, that one converts a MethylSet into a RatioSet, You want to directly create a RatioSet. Do this by tmp = RatioSet(Beta = betaM) (you can also supply CN estimates if you have those.). Then you have to set the annotation correctly, the easiest is to library(minfiData) annotation(tmp) = annotation(MsetEx) Then you convert to GenomicRatioSet by tmp2 = mapToGenome(tmp) Best, Kasper On Thu, Oct 29, 2015 at 3:13 PM, Sally [bioc] <noreply@bioconductor.org> wrote: > Activity on a post you are following on support.bioconductor.org > > User Sally <https: support.bioconductor.org="" u="" 8931=""/> wrote Question: > Loading beta values into minfi <https: support.bioconductor.org="" p="" 73941=""/>: > > > Hi there, > > I have only beta values available to me in a matrix from 450k array data. > I am trying to load the values into minfi as a GenomicRatioSet but keep > getting the same error: > > > ratioSet <- ratioConvert(betaM, what="beta", keepCN=TRUE) > > > Error in (function (classes, fdef, mtable) : unable to find an > inherited method for function ‘ratioConvert’ for signature ‘"matrix"’ > > I tried to make the matrix a dataframe instead and I get the same error > except with the word "matrix" replaced with "data.frame". > > I would like to use the getSex check in minfi and this requires loading in > the GenomicRatioSet. > > Any help you can provide would be greatly appreciated. > > > > ------------------------------ > > Post tags: minfi, 450k > > You may reply via email or visit Loading beta values into minfi >