Hi, all!

I'm in trouble with installing "HPO.db" R package on linux as below. 

> install.packages("HPO.db_1.7.tar.gz")
inferring 'repos = NULL' from 'pkgs'
* installing *source* package ??HPO.db?? ...
** R
** inst
** preparing package for lazy loading
Creating a generic function for ??as.list?? from package ??base?? in package ??HPO.db?
** help
*** installing help indices
** building package indices
** testing if installed package can be loaded
Error in sqliteSendQuery(con, statement, bind.data) : 
  error in statement: disk I/O error
Error in sqliteSendQuery(con, statement, bind.data) : 
  error in statement: disk I/O error
Error : .onLoad failed in loadNamespace() for 'HPO.db', details:
  call: sqliteSendQuery(con, statement, bind.data)
  error: error in statement: disk I/O error
Error: loading failed
Execution halted
ERROR: loading failed
* removing ??/home/caefs/brlee0920/local/src/R/R-3.2.5/library/HPO.db??
Warning message:
In install.packages("HPO.db_1.7.tar.gz") :
  installation of package ??HPO.db_1.7.tar.gz?? had non-zero exit status

and this is my sessionInfo.

> sessionInfo()
R version 3.2.5 (2016-04-14)
Platform: x86_64-pc-linux-gnu (64-bit)

locale:
 [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
 [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
 [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
 [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
 [9] LC_ADDRESS=C               LC_TELEPHONE=C            
[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       

attached base packages:
[1] parallel  stats4    stats     graphics  grDevices utils     datasets 
[8] methods   base     

other attached packages:
[1] RSQLite_1.0.0        DBI_0.4              AnnotationDbi_1.32.3
[4] IRanges_2.4.8        S4Vectors_0.8.11     Biobase_2.30.0      
[7] BiocGenerics_0.16.1  BiocInstaller_1.20.1

loaded via a namespace (and not attached):
[1] tools_3.2.5

It would be very appreciated if you share any idea about this problem.

Thank you.

Thanks for the report. HPO.db is not a Bioconductor package. It seems HPO.db has not been updated to work with the latest version RSQLite.  See A: GO.db installation error for more details. You can try and install a previous version of RSQLite or patch HPO.db source code.