Hi,

I used minfi package to analyze 450K methylation data. I got a list of regions that are differentially methylated.

I would like to know how can i convert the DMR regions into genes to asses which genes are hypo/hyper methylated.

Thank you.

Does ?nearest help you?

Hi James,

nearest helped me to find the nearest gene to the DMR.

nearest(x, subject, select ="all")

returns all overlapping regions which are mostly redundant transcript, since i am interested in unique gene names I used

nearest(x, subject) #arbitrary is the default.

How to ensure that a single DMR (identified by bump hunter in minfi library ) is overlapping only with one gene? Is it possible that DMR overlaps with more than one gene?

Thank you.