Research Associate in Computational Biophysics, University of Manchester
Job reference: BMH-017047
Location: Oxford Road, Manchester, UK Closing date: 19/08/2021 Salary: £32,816 per annum Employment type: Fixed Term Faculty/Organisation: Biology, Medicine & Health School/ Directorate: Molecular & Cellular Function Hours per week: Full Time Contract Duration: 01 August 2021 until 31 July 2024
This is a Postdoctoral Research Associate opportunity to take part in the BBSRC funded project: Prospecting for pH-sensors in host and pathogen systems. This post, based at The Manchester Institute of Biotechnology at The University of Manchester, UK, is available from 1st August for 3 years.
You will participate in a challenging and exciting project to develop models for understanding pH-dependence in biology. The focus of this position is computational, but with biophysical collaboration for testing predictions programmed into the work plan. Algorithms to predict pH-dependent effects have been developed, but their application to biological systems has been largely piecemeal, studying individual elements. This project seeks to apply prediction methods to detect pH-sensing across a range of biological processes, including virus infection and adaptation to altered pH in cancer, informed where possible by high throughput datasets. Specific systems and pH-sensors will be tested in a biophysics collaboration, thus benchmarking the model. Our aim is develop a broadly applicable model for discovering pH-sensors, to make it available through web tools, and to encourage usage across biological fields, recognising the widespread evolution of pH-dependent mechanisms in intracellular and extracellular environments. The overall philosophy for developing and presenting methods follows that used for existing tools available at our website, www.protein-sol.manchester.ac.uk.
This project is a collaboration between 3 groups at the University of Manchester, Dr Jim Warwicker (algorithm development), Professor Perdita Barran (biophysical testing of pH-sensors), and Dr Siddharth Banka (genetics).
The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance.
Enquiries about the vacancy, shortlisting and interviews: Name: Dr Jim Warwicker, Email: email@example.com.
General enquiries: Email: firstname.lastname@example.org
This vacancy will close for applications at midnight on the closing date.
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