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PureCN is able to predict germline vs. somatic status of mutations in the absence of a matched normal. Has a performance evaluation of this capability been published or is otherwise available?
PureCN is able to predict germline vs. somatic status of mutations in the absence of a matched normal. Has a performance evaluation of this capability been published or is otherwise available?
On TCGA data: https://ascopubs.org/doi/10.1200/CCI.19.00130
A similar method published shortly after ours with more comprehensive benchmark: https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-017-0296-8
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