PureCN performance of somatic/germline status prediction without matched normal?
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twtoal ▴ 10
@twtoal-15473
Last seen 8 months ago
United States

PureCN is able to predict germline vs. somatic status of mutations in the absence of a matched normal. Has a performance evaluation of this capability been published or is otherwise available?

SomaticMutation GermlineMutation PureCN • 252 views
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@markusriester-9875
Last seen 7 weeks ago
United States

On TCGA data: https://ascopubs.org/doi/10.1200/CCI.19.00130

A similar method published shortly after ours with more comprehensive benchmark: https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-017-0296-8

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