Hi,

I currently have several 10x genomics sc-RNA-seq datasets that each contain a small population of spike-in cells with higher copy number variation that my analytical sample cells.

I was interested in using this spike in population to normalize my analytical sample cells, but I am not sure which packages/functions may allow me to do this.

I am relatively new to computational biology, so I am still trying to understand how I might actually normalize my analytical sample cells to the spike in cells.

Thank you