I'm trying to wrap my head around the nondetects package.

Looking at the oncogene2013 data set, they say they used 2 cell lines, three treatments, and 4 replicates. That's 24 samples, which is the number of columns in exprs().

What's not discussed is the number of technical replicates, which I assume they must have done.

Can nondetects impute a dataset that includes technical replicates? Or do you just toss the replicates that don't work and use the geometric mean of anything remaining?

Thanks -Ed