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Question: What's the difference between p.adjust and qvalue?
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gravatar for tjiagoM
6 months ago by
tjiagoM10
tjiagoM10 wrote:

In the result of an enrichGO() we have two columns, p.adjust and qvalue. I guess p.adjust is the pvalue modified after considering FDR, but then what actually is the qvalue?

 

ADD COMMENTlink modified 6 months ago by Guido Hooiveld2.2k • written 6 months ago by tjiagoM10
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gravatar for Guido Hooiveld
6 months ago by
Guido Hooiveld2.2k
Wageningen University, Wageningen, the Netherlands
Guido Hooiveld2.2k wrote:

From the help page (?enrichGO):

pAdjustMethod: one of "holm", "hochberg", "hommel", "bonferroni", "BH", "BY", "fdr", "none".

Note: default = "BH".

 

qvalue: alternative approach/algorithm to calculate FDR/control for multiple testing. For more details see the package qvalue here.

Note: default value is 0.2. 

 

ADD COMMENTlink modified 6 months ago • written 6 months ago by Guido Hooiveld2.2k

Exactly, I saw that, but isn't that the same meaning as of an adjusted p-value? Because calculations of FDR are meant to change the pvalue, right?

ADD REPLYlink written 6 months ago by tjiagoM10
1

Yep, the aim of all 'FDR algorithms' is the same, but how they exactly work differ between the algorithms. See e.g. this thread + links conceptual question about FDR, FDR adjusted p-value and q-value for an easy accessible overview, and confusion regarding nomenclature. The thread @ Biostars here also discusses this question (and links to the same BioC thread).

ADD REPLYlink modified 6 months ago • written 6 months ago by Guido Hooiveld2.2k

Ok, the package mentions that they are not creating adjusted pvalues. I will look with more attention, thanks.

ADD REPLYlink written 6 months ago by tjiagoM10
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