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Question: ReactomePA enrichMap function - a question regarding the connections between nodes
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gravatar for juls
11 months ago by
juls0
juls0 wrote:

Dear all,

Using the ReactomePA package I have visualised the enrichment results by means of the enrichMap function (for an example see the original publication, Figure 1 http://pubs.rsc.org/en/content/articlepdf/2016/mb/c5mb00663e).

I am wondering though what the connections between the nodes mean? When does a connection arise? When there is (sufficient) overlap between the gene sets of the pathway or do the connections come from Reactome database? 

Thank you for your help/answers!

 

 

ADD COMMENTlink modified 11 months ago by Lluís R330 • written 11 months ago by juls0
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gravatar for Lluís R
11 months ago by
Lluís R330
European Union
Lluís R330 wrote:

The connection between the dots is half the Dice coefficient. The intersection of genes in each pathway divided by the total amount of genes in these two pathways.

The color of the nodes is a representation of the p-value of the pathway. And the size represents the number of genes in the pathway. 

See the source code.

ADD COMMENTlink written 11 months ago by Lluís R330
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