Hi,

I'm running pathway analysis with goseq but had the error : In pcls(G) : initial point very close to some inequality constraints : when plotting the nullp. I'm not sure if this is an issue or not. The curve doesn't start on the y-axin from zero but 0.004 but after that the curve is pretty similar to the ones in examples. However, the dots are plotted quite randomly across the field.

Is this a concern and if is how might I solve this?

Despite this the results seem to match to our differential expression analysis results.

Really appreciate the help!