Find significant genes related to a specific disease
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Will • 0
@will-23665
Last seen 12 months ago
Italy

Hi, after an RNASeq analysis using Limma I obtained a table full of genes by using the topTable() function. So I have a csv, comma separated, formed by GENEID(ensemble), ENTREZID, SYMBOL, logFC, AveExpr, t, P.Value, adj.P.Val, z.std.

Is there a way to search the most significant genes associated to a specific disease mentioned in some papers? Because for e.g. the top 5 genes are not mentioned in any paper to be related to some diseases. The table is formed by 40000 genes, so searching them on the google scholar is very complicated.

Any suggestions?

GeneExpression RNASeqR limma • 304 views
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@antonio-miguel-de-jesus-domingues-5182
Last seen 5 months ago
Germany

I suggest the portal enrichr, example, for which there is an R package that allows you to make queries in R (not bioconductor):

https://cran.r-project.org/web/packages/enrichR/index.html