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15
votes
17
replies
1.3k
views
Why p value inconsistent when using different number of pathway score?
limma
28 days ago • updated 16 days ago
Chris
▴ 10
15
votes
23
replies
2.0k
views
The difference when using Limma compare between 3 conditions vs 2 conditions
limma
7 weeks ago • updated 18 days ago
Chris
▴ 10
11
votes
5
replies
7.4k
views
Theoretical WGCNA Question
WGCNA
Theory
Scale-Free Topology
updated 29 days ago by
Garrett
• 0 • written 9.2 years ago by
brohawndg
▴ 150
10
votes
10
replies
1.9k
views
SGSeq: moving toward diffex from SGSeq analysis
sgseq
rnaseq
updated 2 days ago by
Leonard Goldstein
▴ 220 • written 6.7 years ago by
Sylvain Foisy
▴ 80
7
votes
39
replies
5.8k
views
Ensembl plants at annotationHub?
ensembl
ensembldb
plant
arabidopsis thaliana
annotationhub
updated 19 hours ago by
Daniele
• 0 • written 5.5 years ago by
Guido Hooiveld
★ 4.0k
6
votes
5
replies
475
views
Estimating Cell Counts for EPIC V2 array data
FlowSorted.Blood.EPIC
minifi
written 11 weeks ago by
Kim
• 0
6
votes
10
replies
1.7k
views
Which input file is used for DGEList in EgdeR?
salmon
edgeR
tximport
nf-core
gene_counts
updated 29 days ago by
i.atanasoai
• 0 • written 15 months ago by
mohammedtoufiq91
▴ 10
6
votes
19
replies
2.6k
views
DESeq2 a lot of genes showing up as differentially expressed that only have 1 sample with any expression
deseq2
updated 18 days ago by
Sey R.
• 0 • written 4.6 years ago by
hsbio
▴ 10
6
votes
12
replies
5.1k
views
BiocFileCache/ExperimentHub/AnnotationHub temporary ERROR
BiocFileCache
AnnotationHub
ExperimentHub
6 months ago • updated 26 days ago
shepherl
3.9k
5
votes
6
replies
2.8k
views
Although I successfully installed the package "simpleaffy'' , I cannot library it. Why?
simpleaffy
updated 16 days ago by
James W. MacDonald
65k • written 2.3 years ago by
yanchangjian2019
• 0
5
votes
3
replies
305
views
Log-cpm values from limma
limma
edgeR
RNASeq
updated 8 days ago by
Gordon Smyth
50k • written 4 weeks ago by
Shaimaa Gamal
• 0
5
votes
8
replies
8.9k
views
Limma design with continuous and categorical covariates
limma
batch effect
covariates
microarray
updated 25 days ago by
hortense96
• 0 • written 7.8 years ago by
dmcleanuk
▴ 30
4
votes
0
replies
135
views
News:
Bioconductor 3.19 is Released!
Release
Bioconductor
Packages
Software
16 days ago
shepherl
3.9k
4
votes
9
replies
241
views
Can DESeq2 rlog normalized matrix reflects time course result directly?
DESeq2
timecoursedata
GeneExpression
updated 2 days ago by
ATpoint
★ 4.1k • written 3 days ago by
pangtaihin
• 0
4
votes
5
replies
317
views
Method to find pathways different between 2 groups
fgsea
GSVA
CAMERA
12 days ago • updated 3 days ago
Chris
▴ 10
4
votes
6
replies
469
views
FilterByExpr low counts with small sample size
edgeR
4 weeks ago • updated 26 days ago
Jonathan
▴ 10
4
votes
9
replies
3.1k
views
Create protein sequences including variants from a VCF file
VariantAnnotation
customProDB
updated 3 days ago by
Yun
• 0 • written 5.2 years ago by
daniel.magnus.bader
▴ 50
4
votes
9
replies
490
views
Memory errors using read.bismark?
dmrseq
bsseq
5 weeks ago • updated 11 days ago
Juan Higareda
• 0
4
votes
2
replies
620
views
Why does GSEA on edgeR results for randomized samples give highly significant p-values?
fgsea
edgeR
15 days ago • updated 12 days ago
gene_bioconductor
▴ 10
3
votes
5
replies
290
views
Help with running egsea()
EGSEA
11 days ago • updated 10 days ago
Chris
▴ 10
3
votes
3
replies
368
views
permutation test in edgeR
rna-seq
edgeR
updated 27 days ago by
Gordon Smyth
50k • written 5 weeks ago by
Netanel
• 0
3
votes
10
replies
447
views
Extremely small p-values using Limma for proteomic data
Proteomics
limma
updated 8 days ago by
James W. MacDonald
65k • written 11 days ago by
Abbey
• 0
3
votes
4
replies
274
views
Store output of matchPWM()
biostrings
Biostrings
17 days ago • updated 4 days ago
mat149
▴ 70
3
votes
4
replies
513
views
Mac ARM64 build report for BioC 3.19 from 'kjohnson3' reporting ERROR which it does not happen in Linux
GenomAutomorphism
updated 10 days ago by
Mike Smith
★ 6.5k • written 12 days ago by
robersy
• 0
3
votes
1
reply
148
views
How to save the DEXSeq results
DEXSeq
updated 12 days ago by
Michael Love
42k • written 12 days ago by
Sara
• 0
3
votes
1
reply
328
views
Use of negative binomial model for exponential decay rate estimation using DESeq (or similar)
DESeq2
updated 24 days ago by
Michael Love
42k • written 25 days ago by
i.sudbery
▴ 40
3
votes
1
reply
1.5k
views
Limma without eBayes, is it indistunguishable from Ordinary Least Square?
Limma
ebayes
bayesian
ls
updated 10 days ago by
Gordon Smyth
50k • written 5.6 years ago by
CantExitVIM
▴ 10
3
votes
2
replies
231
views
Cannabis and KEGGgraph
KEGGREST
GenomicDistributionsData
KEGGgraph
KEGG
updated 26 days ago by
Guido Hooiveld
★ 4.0k • written 28 days ago by
fernanda.backsouza
▴ 10
3
votes
3
replies
251
views
DESeq2 - dispersion estimation when there is none
DESeq2
updated 25 days ago by
Michael Love
42k • written 26 days ago by
WardDeb
• 0
3
votes
4
replies
260
views
Help with error using camera() in limma
CAMERA
limma
18 days ago • updated 17 days ago
Chris
▴ 10
3
votes
3
replies
269
views
DESeq2: Contrast for two conditions combined versus one condition (A+B_vs_C)
DESeq2
contrasts
updated 19 days ago by
ATpoint
★ 4.1k • written 19 days ago by
bioinf
▴ 10
3
votes
1
reply
1.5k
views
Job:
Post Doctoral position in AI (Deep learning / Machine learning) approaches for Cancer Research, MRC Cancer Unit, University of Cambridge, UK
job
Job
machine learning
deep learning
computational biology
written 6.3 years ago by
Shamith.Samarajiwa
▴ 180
2
votes
1
reply
168
views
minfi latest update for EPIC V2 chip
minfi
minfiDataEPIC
updated 11 days ago by
James W. MacDonald
65k • written 11 days ago by
e1271094
• 0
2
votes
4
replies
282
views
Error EPICv2 ChAMP
ChAMPdata
IlluminaHumanMethylationEPICv2anno.20a1.hg38
ChAMP
updated 26 days ago by
James W. MacDonald
65k • written 4 weeks ago by
Mirella Aurora
• 0
2
votes
7
replies
375
views
deseq2 results
DESeq2
DifferentialExpression
rnaseqGene
DifferentialRegulation
10 days ago • updated 7 days ago
sajadahmad41454
• 0
2
votes
1
reply
67
views
How to design DEXSeq formula for multiple variables
DEXSeq
updated 3 days ago by
Alejandro Reyes
★ 1.9k • written 5 days ago by
Sara
• 0
2
votes
5
replies
258
views
How to retrieve gene ontology GO class from gene list?
GO.db
goTools
updated 23 days ago by
James W. MacDonald
65k • written 24 days ago by
bandconductor
• 0
2
votes
5
replies
211
views
Error while installing BiocManager::install("org.Vdahliae.eg.db")
org.vdahlaie.eg.db
Bioconductor
3 days ago • updated 1 day ago
Patadù
▴ 10
2
votes
3
replies
254
views
Too many significant genes when integrating gtex and tcga
RNA-seq
DESeq2
updated 13 days ago by
ATpoint
★ 4.1k • written 14 days ago by
Reza
• 0
2
votes
2
replies
274
views
error in limma , contrast.matrix Number of rows of contrast matrix must match number of coefficients in fit
limma
11 days ago • updated 5 days ago
zzrammal
• 0
2
votes
2
replies
214
views
OrgDb for maize
clusterProfiler
OrgDb
biomaRt
Zea_mays
updated 29 days ago by
James W. MacDonald
65k • written 29 days ago by
sansan
• 0
2
votes
9
replies
427
views
Batch/method effect correction on a cohort of patients with RUVseq and DESeq2
DESeq2
RUVSeq
RUVseq
BatchEffect
DES
updated 22 days ago by
James W. MacDonald
65k • written 23 days ago by
Alexandre
• 0
2
votes
13
replies
480
views
Trying to use enrichGO
clusterProfiler
GenomicDistributionsData
KEGG
27 days ago • updated 23 days ago
fernanda.backsouza
▴ 10
2
votes
1
reply
141
views
Trim/Filter out-of-bounds GRanges
GenomicRanges
updated 12 days ago by
Michael Love
42k • written 12 days ago by
mat149
▴ 70
2
votes
2
replies
356
views
Importing a GraphNEL into Cytoscape with RCy3 with error: "Error in cyrestPUT(paste("networks", net.suid, "tables", tbl, sep = "/"), : object 're…
RCy3
6 days ago • updated 2 days ago
Matthew Thornton
▴ 360
2
votes
2
replies
224
views
fgsea significant result
fgsea
13 days ago • updated 12 days ago
Chris
▴ 10
2
votes
3
replies
95
views
Problem installing ChAMP on a MacBook
ChAMP
updated 2 days ago by
shepherl
3.9k • written 2 days ago by
Galia
• 0
2
votes
2
replies
1.1k
views
limma for gene expression analysis with big and unbalanced sample size
limma
microarray
statistics
updated 17 days ago by
XW
• 0 • written 8.0 years ago by
tati6406
• 0
2
votes
3
replies
117
views
How to correctly adjust for gender in edgeR
design
glm
edgeR
updated 2 days ago by
Gordon Smyth
50k • written 3 days ago by
Guillermo
• 0
2
votes
5
replies
306
views
get BM error
ensembldb
updated 24 days ago by
James W. MacDonald
65k • written 24 days ago by
Fara
• 0
180 results • Page
1 of 4
Recent ...
Replies
Answer: Numerical differences in DESeq2 output depending on different design matrix cons
by
Michael Love
42k
Yes there can be small numerical differences in the estimated quantities because of how the algorithms decide to stop iterating.
Answer: DESeq2- Mysterious interaction suppresses DEGs
by
Michael Love
42k
Removing samples from one group nevertheless changes the variance estimation (dispersion) for all comparisons. So you could have pushed one…
Comment: Ensembl plants at annotationHub?
by
Daniele
• 0
Hi, I'm using Ensembl Plants release 59 with the IWGSC RefSeq v1.1 gene annotation. Thanks a lot for replying so quickly!
Comment: Numerical differences in DESeq2 output depending on different design matrix cons
by
swbarnes2
★ 1.4k
If you restrict yourself to, say, genes with a baseMean > 50, are the numerical differences between the two designs significant?
Comment: DESeq2- Mysterious interaction suppresses DEGs
by
shaunpeterson
• 0
The images I tried to attach didn't attach. Here is the PCA (MDS) of all the samples, with the Cortex outlier highlighed. ![enter image de…
Votes
Answer: Error while installing BiocManager::install("org.Vdahliae.eg.db")
Comment: How can I create a eigencorplot of pca created from deseq2 object with PCAtools
Answer: Importing a GraphNEL into Cytoscape with RCy3 with error: "Error in cyrestPUT(pa
Answer: Importing a GraphNEL into Cytoscape with RCy3 with error: "Error in cyrestPUT(pa
Rsubread counting peaks ATACseq
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