I have results of targeted sequencing. It is several csv files with information about amplicons (unique id of amplicon and number of reads). It looks like that (*image below). And I have to compare two coverage profiles of two samples. There are several methods to do that (Pearson correlation, Euclidean distance, Chi-square, t-test, clustering analysis and so on...), but I don't quite sure what will be statistically correct?
The goal is to validate the result. I have two samples (control and new) and I want to know that the coverage profile of new sample is the same with control sample.
*important moment: inside sample there is kind of competition for reagents, so if one amplicon will be "covered" high-covered then others will be "covered" less.